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Struggling with weight gain in your 40s or 50s—even though your habits haven't changed? Hormonal shifts during perimenopause and menopause can make it harder to lose weight, especially around the midsection. GLP-1

Figure 3: Structure of the pancreas with Islet of Langerhans, credit: BruceBlaus, Wikimedia Knowledge about the pancreas deepened further as a result of research by Ernest Starling and his brother-in-law William Bayllis, two British physiologists at UCL

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The lap band procedure is less invasive, but more likely to fail and require re-do surgery or initiation of GLP-1 treatment based on long-term outcome studies