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Cardiovascular Outcomes Liraglutide (LEADER trial): 13% reduction in major adverse cardiovascular events (MACE) in patients with Type 2 diabetes and high cardiovascular risk Statistically significant cardiovascular protection Semaglutide (SELECT trial): 20% reduction in MACE in patients with obesity and established cardiovascular disease Studied specifically for cardiovascular outcomes in obesity (not just diabetes) Both medications provide cardiovascular protection, but semaglutide’s evidence is more recent, more robust, and specifically applicable to patients with obesity regardless of diabetes status
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This is not a required schedule: If a dose is not tolerated, a healthcare provider may delay escalation, keep the patient at a lower dose, or adjust the treatment plan
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