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No pharmacotherapy is approved for the treatment of NAFLD and, currently, the cornerstone treatment is lifestyle modifications focusing on bodyweight loss, notoriously difficult to obtain and even more difficult to maintain

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Still, while the new combinations “would be great for people who need to lose more weight,” Korner said, “not everyone needs the so-called big gun.” Drugs like retatrutide may be most appropriate for someone who has a body mass index above 45 – above 30 is considered obese – and for whom existing drugs haven’t worked sufficiently, Dushay said