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A 3d rendering of pre-filled GLP-1 receptor agonist pens, used for the treatment of type 2 diabetes or for weight management

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(Source: ASMBS, June 2025) A 2026 network meta-analysis of randomized controlled trials (30 trials, 20,015 patients) found metabolic/bariatric surgery achieved significantly greater reductions than GLP-1 receptor agonists in total weight loss (−10.3 percentage points), BMI (−4.5 kg/m²), body weight (−11.7 kg), waist circumference (−12.6 cm), and HbA1c (−0.5%) at under 104 weeks

such as those who are obese or have weight