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Injected subcutaneously, a peptide can yield a bioavailability of up to 50%, which is worlds above the sub-1% you might get from an orally ingested alternative.18 19 The reason for such a large disparity is that orally ingested peptides must pass through your digestive tract, where they can easily degrade, and peptide molecules are often too large to pass easily through your intestinal lining.19 It’s true there are oral peptides that leverage absorption-enhancing technologies, but even with them you’re getting maybe just a bit closer to 2% bioavailability — little improvement over non-enhanced forms.20 It’s also true that orobuccal administration (through the linings of the mouth) provides a much more bioavailable route than ingestion, but even through that route the relative absorption is less than half that of subcutaneous injection.37 Things being as they are, if you want to get the most out of your peptide therapy for weight loss, subcutaneous injection is the way to go — at least until the technology improves enough to raise oral alternatives to the same level of absorptiveness

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Medical weight loss with GLP-1 receptor agonist medications is a clinician-supervised program that uses semaglutide or tirzepatide to reduce appetite, regulate blood sugar, and promote sustained fat loss